Gastric lavage may instead increase the severity of poisoning by dissolving the substance and enhancing its absorption. Big - Alcohol, ecstasy, amphetamines, anticholinergics, ß-blockers.Small - Opiates, organophosphates, other cholinergics.Reflexes down in CNS depressants up in anticholinergics and sympathomimetics.Ĭonvulsions – antichol, symp, CO, lithium, tricyclics, neuroleptics, alcohol withdrawal.Ĭoma unlikely in salicylates or paracetamol (unless liver failure). Myocardial depression – tricyclics, b blockers, Ca blockers. Incidence: Paracetamol > ibuprofen > aspirin > SSRIs > tricyclics.Īn acute overdose less than 10 times a single therapeutic dose seldom causes life-threatening symptoms apart from overdose with narcotics, paracetamol, lithium, digoxin and warfarin.Īrrythmias up to 24h if slow release preparation. Much of this is derived from the PACT module 'major intoxication'.
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